Non - nucleoside reverse transcriptase

Non-nucleoside reverse-transcriptase inhibitors (NNRTIs)

Lino ddagala erikozesebwa mu kujjanjaba akawuka ka HIV. Empeke za NNRTIs ziziiza (inhibit) ekirungo Reverse transcriptase (RT) ekiyamba akawuka okwekubisaamu oba okweyaluza (replication). Abanoonyereza ku ddagala ly’akawuka ekirungo kya RT kye kimu ku bye batunuulidde okugaziyirizaako.

Ekirungo (enzyme) ya reverse transcriptase eyamba entondeka (RNA) y’akawuka ka HIV eba mu nkula y’oluwuzi olumu (RNA single stranded) okwekyusa n’efuuka ya wuuzi bbiri (double stranded DNA). DNA eyamba okuzimba obutoffaali obw’obulamu bw’ekintu kyonna omuli n’eky'akawuka HIV.